Assistant Professor of Biology
Ph.D. University of California, San Francisco, 2003
Voicemail: (707) 664-2931
Office: Darwin 211
Washington University in Saint Louis.
Molecular and Cellular Biology, Signal Transduction,
My research efforts focus on how cells of the immune system, specifically T cells, are activated to protect us from pathogens. T cells are vital for the establishment of protective immunity in response to vaccination and subsequent infection. Their activation requires a delicate balance between having the sensitivity to respond to low amounts of pathogens, but at the same time, not respond to "self" which would lead to the development of autoimmune diseases such as lupus or rheumatoid arthritis.
In particular, I am interested in the intracellular signaling pathways that are responsible for T cell activation. This complex process involves the dynamic interplay between a multitude of signaling molecules, ultimately resulting in differentiation and proliferation. By taking a molecular and biochemical approach to dissecting the intricate pathways required for T cell activation, we hope to futher understand these complicated mechanisms and determine whether these pathways are also utilized by organisms that do not have traditional T cells.
Lin, J., Harding, A., Giurisato, E., and Shaw, A.S. (2009) KSR modulates the sensitivity of the MAPK pathway in T cells without altering fundamental system outputs. Mol Cell Biol. 29:2082-91.
Giurisato, E., Lin, J., Harding, A., Cerutti, E., Cella, M., Lewis R.E., Colonna, M., and Shaw, A.S. (2009) The MAP kinase scaffold KSR1 is required for recruitment of ERK to the immunological synapse. Mol Cell Biol. 29: 1554-64
Kao, H., Lin, J., Littman, D.R., Shaw, A.S., and allen, P.A. (2008) Regulated movement of CD4 in and out of the immunological synapse. J Immunol. 181(12):8248-57.
Zhu, J.W., Brdicka, R., Katsumoto, T.R., Lin, J., and Weiss, A. (2008) Structurally distinct receptor-type protein tyrosine phosphatases CD45 and Cd148 both regulat B cell and macrophage immunoreceptor signaling. Immunity. 28:183-196.
Lin, J., and shaw, A.S. (2005) Getting downstream without a raft. Cell. 121:815-816.
Lin, J., Zhu, J.W., Baker, J.E., and Weiss, A. (2004) Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells. J Immunol. 173:2324-2330.
Lin, J., and Weiss, A. (2003) The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J Cell Biol. 162:673-682.
Lin, J., and Weiss, A. (2001) Identification of the minimal tyrsine residues required for linker for activation of T cell function. J Biol Chem. 276:29588-29595.
Lin, J., and Weiss, A. (2001) T cell receptor signalling. J Cell Sci. 114:243-244.
Lin, J., Weiss, A., and Finco, T.S. (1999) Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. J Biol Chem. 274:28861-28864