Genomes: small to large; single molecule or segmented Terminology 102a: Genetic mapping: recombination; reassortment; restriction
maps; transcription maps Terminology 102b: strain; type; variant Mutations: Evolution: Something to think about: Do viruses contribute to
evolution of other organisms? If so, how? [Discussion
topic 3/12]
Nucleic acid structure & composition:DNA or RNA; ss or ds; linear or circular
terminal structures; open reading frames
[ORFs]
conservation strategies; regulatory signals &
strategiesreplicative intermediate [RI]
replicative form [RF]
defective interfering [DI] particlesantigenic drift vs. antigenic shift
types defined by physical changes [genotypic]:
point & insertion/deletion
types defined by effects [phenotypic]: DI
particles, nonsense, temperature-sensitive [ts]
& cold-sensitive [cs], host range, drug
resistance, revertantmutations & fast-forward strategies;
effects
theories of origin of viruses- DNA vs. RNA
macromolecular, retrograde, selfish DNA,
protovirus, primordial RNA, DNA as RNA intermediate
Updated 1/25/04 by thatcher@sonoma.edu