Virology
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	Spring, 2004 Lecture Outline 3/23 HEPADNAVIRIDAE   Hepadnavirus intro: prototype- Hepatitis B virus [HBV] HBV contrasts c HAV: is non-enveloped, in picorna [RNA] delta agent: viroid- naked RNA, req. HBV for transmission HEV: is non-enveloped, in calici [RNA] HCV: is enveloped, in flavi/toga grp [RNA] HGV: RNA virus structure: Australia Ag- 22 nm particle, noninfectious serum Ag a.k.a. HBsAg- hepatitis B surface Ag- Dx marker for HBV Dane particle- rarer, 42 nm c dense core [core Ag = HBcAg] unusual DNA organization: circular minus-strand c break complimentary plus-strand- forms patched circle replication: uses RNA intermediate; complex pattern unique to grp 1. genomic patched circle -> full dsDNA circle in nucleus 2. "pregenomic" RNA made by host transcriptase 3. minus strand DNA copy by viral "reverse transcriptase" 4. plus strand copied using oligomer of DNA as primer [not RNA] Dz: hepatitis & liver cancer possible because HBV dsDNA can integrate into genome; persistent & latent diagnosis & treatment Next up: Small DNA viruses
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