Marburg virus- fatal hemorrhagic fever symptoms & pathology; epidemiology structure: pleomorphic 100-300 nm transcription & replication: S RNA segment: genome(+/-)
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(+)mRNA
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replication N protein ~~~~~~~~~~~~~~~ aaaaaaaaa +
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replicationaaaa
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GPC protein
pathology: not cytolytic, cytotoxicity from T-cell
attack cytopathology & treatment structure: enveloped 100 nm replicated in cytoplasm; process similar to
orthomyxo- pathology: viremia follows bite; multiplies in
susceptible organs Next week: Retroviridae- see CRC, ch 6 & appropriate parts of
Wagner, including ch 20, & on-line
Filoviruses:once in rhabdo family; morphologically
different
long filaments in various shapes, U's & circles
infect range of mammals; reservoir is unknown
Ebola virus- severe hemorrhagic fever, mortality of
50-90%
Arenaviruses:lymphocytic choriomeningitis, Lassa fever,
hemorrhagic fevers
RNA- 2 segments (L & S), appear circular
**ambisense polarity- both plus & minus sense on RNA
strandsstrategy also applies to one grp in bunya family
transcription
translation
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transcription
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translation
genome(+/-)
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see also CRC, Fig. 190- Bunyaviridae,
Phlebovirus
Tacaribe grp- spread to humans from rodent
excreta
*Lassa fever- only one which can spread from human to
human
Bunyaviruses: large grp- insect transmitted; usually
in tropicsseveral spp in US; most common encephalitis
virus in US
several prototypes- e.g.: Bunyamwera & Calif.
encephalitis
transmission- mechanical spread by insect vectors
RNA- 3 segments 6 x 106 d total; minus
strands, except phlebovirus- ambisense like
arenaviruses
bud into Golgi- unique to bunya's
patchy inflammation, neuronal degeneration, edema in
cortexdsRNA viruses: Reoviridae, Partitiviridae,
Cystoviridae- see CRC, ch 7 & appropriate parts of
Wagner, including ch 16, & on-line
Updated 1/25/04 by thatcher@sonoma.edu