Intro: levels of control- eukaryotes [monocistronic
mRNA] cis vs. trans effects challenge for viruses: limited genetic material, host
cell activities, host cell defenses trans-acting factors: E.g.- l,
Papova polycistronic expression: E.g.- Picorna, multipartite,
Toga monocistronic expression: E.g.- Reo, Orthomyxo transcriptional polarity: E.g.- Paramyxo production of nested sets of mRNA: E.g.- Corona cascade of activation: E.g.- Herpes multiple mechanisms demonstrated in [+] strand
RNA plant viruses retroviral control of gene expression splicing in the extreme: E.g.- Adeno
levels of control- prokaryotes
[polycistronic mRNA]
operons; mRNA conformation; signal
transduction
DNA conformation for available sites; type of
RNA pol;
mRNA conformation; nmRNA -> mRNA processing;
signal
transduction
secondary structure as means of regulation: E.g.-
MS2/Qb, Parvo
Next week:Infection & control- read Wagner, ch 7 &
8
Pathogenesis- general mechanisms & effects- read
appropriate parts of Wagner, including ch 4
Updated 1/25/04 by thatcher@sonoma.edu