Virology
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	Spring, 2004 Lecture Outline 5/4 INFECTION & CONTROL Intro: Infection defined To cause an infection, a virus must a. gain entry to the organism [single cells we've covered] b. withstand initial defensive onslaught c. attach to appropriate cell type[s] d. replicate & spread, avoiding defense mechanisms, e.g.: IFN For an infection to continue, virus must produce at rate > clearance rate or it must be able to establish persistence in cells For an infection to be cleared, host must be able to eliminate virus at rate > production and to block persistence by virus Infection patterns Antiviral Effects: Viral Interference, IFN & Immune Response Viral interference: direct vs. indirect reverse interference- enhancement of superinfection Interferon [IFN]: infected cell induced by virus to produce interferon types of IFN & cells producing them induction & effect of IFN therapeutic use of IFN Immune response: [Very brief!!] Abs to viral antigens- primarily act to block adsorption complement [C'] activation phagocytes- bind to Ab-coated or C'-coated particles diagnosis: monitoring infection & ID etiology viral counter attack on IR: superantigens & induction of autoimmunity antiviral drugs = virucides [Wagner Table 8.3] vaccines: best route of prevention Plant responses to infection: lectins; chemotactic factors induced by infection; antimicrobial peptides; natural resistance- genetic local lesion response- hypersensitivity tolerance- Dz spreads systemically Next up: Pathogenesis & cytopathology
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