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Lecture schedule

Discussion schedule

Journal presentation topic schedule

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Spring, 2004 Lecture Schedule:

Click on lecture topics to access outlines

Reading

Date:


Topic:


Wagner:

1/27

Introduction & class mechanics

1/29

Nature of viruses; general structure

Ch 1,2

2/3

Basic structures & functions

Ch 2,5

2/5

Basic methodology [other reading available]

Part 3

2/10

Overview of genomic organization & evolution

Part 4

2/12

Overview of replication/infection cycle

Ch 2,6

2/17

Taxonomy & ICTV systematics

Ch 5

2/19

Nonenveloped [+] strand RNA viruses; Leviviridae

Ch 15

2/24

NO CLASS- Independent assignment

2/26

Picorna-, Calici- & Noda- viridae

Ch 15

3/2

Enveloped [+] strand viruses; Toga-, Flavi-, & Corona- viridae; "The Great Paper Chase" begins- See example

Ch 15

3/4

[-] strand RNA viruses; Rhabdo-,Paramyxo-, Orthomyxo- viridae

Ch 16

3/9

Filo-, Bunya-, & Arena- viridae

Ch 16

3/11

MIDTERM I [Through ssRNA (+) strand viruses]

3/16

Double-stranded RNA viruses; Reo-, Partiti- & Cysto- viridae

Ch 16

3/18

Viruses using reverse transcriptase; Retroviridae; *Paper Chase question #4 proposals due

Ch 20

3/23

Reverse transcriptase continued; Hepadnaviridae

Ch 21

3/25

Small genome DNA viruses

Ch 17

3/30

Small genome DNA phage; Parvo- & Papova- viridae

Ch 17

4/1

Adeno- & Herpes- viridae; DNA insect viruses

Ch 17,18

4/5-9

SPRING BREAK!!!

4/13

"The Heartbreak of Herpes" & "The World Conquers Pox"

Ch 19

4/15

Myo- & Sipho- viridae; "The Great Paper Chase" ends

Ch 19

4/20

Viroids & prions

pp 281-283

4/22

MIDTERM II [(-) strand RNA viruses through DNA viruses]

4/27

Expression control & strategies

4/29

Expression control & strategies continued

5/4

Infection & control

Ch 7,8

5/6

Pathogenesis- mechanisms & effects

Ch 4

5/11

Tumorigenesis- DNA vs. RNA tumor viruses

5/13

Emerging viruses & future trends; Review

Ch 22

5/18

FINAL 5-7 pm

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Texts: [back]
Wagner & Hewlett, 2004. Basic Virology 2e, Blackwell Scientific.

Note on readings: The arrangement of material in the Wagner book is such that you will need to be flexible and fluid in finding and reading the appropriate parts. The chapters listed above will direct you to some, but not all, of the related information. Use of the index will be indispensable. For some of the lecture topics, the associated material is either not well isolated or is not developed in the book. The Ackermann book is not so much read as absorbed. The diagrams will help to anchor the structures and functions of the viruses.

Other references & resources: On reserve in the library is a copy of Ackermann, et al., 1995, Atlas of Virus Diagrams; Ackermann, et al., 1998, Virus Life in Diagrams; and selected diagrams from Ackermann, et al., 2001, Viral Pathogenesis in Diagrams, arranged in page order, table of contents included. These images, along with images from your texts will be used in lecture. For methods, in addition to Part 3 in Wagner, you will find on reserve Appendix 1 from Levy, et al., 1994, Virology. Also, the computer exercises will introduce you to both on-line resources and to on-line databases of current literature. You should find the on-line information a valuable asset , allowing you to readily extend beyond the limitations of the text. [back]

Lecture organization & content: Lectures are organized into 3 phases: 1) a comprehensive introduction of molecular virology and principles relating to the study of viruses, 2) an in-depth look at representative viruses, starting with the smallest and simplest RNA viruses, then progressing to successively more complex viruses to the largest and most complex DNA viruses, followed by the difficult-to-classify viroids and prions, and finally 3) a comparative look at viral expression strategies, viral pathogenic mechanisms, and host responses. Lecture material is drawn from your texts, other reference texts, journal literature, and on-line resources, including ICTV, NCBI, and CDC. If you miss a lecture, be sure to get a copy of notes from someone, since there is likely to be material not found in your text. For your convenience, lecture note outlines can be obtained by clicking on the linked lecture titles in the schedule above. These should help you in your background reading and should serve as a guide during lecture.


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Spring, 2004 Discussion Schedule

Date:


Room:


Topic:


1/27;
1/29

D122

Group discussion: Current problems & issues in virology; Discussion section mechanics

2/3; 2/5

D207

Viral structural modeling- computers & development of handmade models [Lab scheduled 6:50-8:50]

2/10;2/12

D122

Viral structural model show- presentation of models; Group discussion: Basic methodology- choices

2/17;2/19

D207

Introduction to bioinformatics & databases; Independent assignment: Bioinformatics searches [Lab scheduled 6:50-8:50]

2/26

D122

Discussion: Bioinformatics; Review & study strategies for midterm

3/2; 3/4

D207

Bioinformatics Project [Lab scheduled 6:50-8:50]; "The Great Paper Chase" strategies

3/9

D122

Group discussion: Viruses as agents of evolution; Review

3/16;3/18

D122

Bioinformatics- troubleshooting & using applications

3/23;
3/25

D122

Journal presentations

3/30; 4/1

D122

Journal presentations

4/5-9

SPRING BREAK!!!

4/13;
4/15

D122

Qualitative methods demonstration; Journal presentations

4/20;
4/22

D229

Quantitative assays: set up [Be prepared to check your results 4/25 in D234] (Click link for lab protocol)

4/27;
4/29

D122

Quantitative assays: results; Journal presentations

5/4;
5/6

D122

Group discussion: Making an effective HIV vaccine; Journal presentations

5/11;
5/13

D122

Group discussion: Future issues in virology; Journal presentations


D207 Computer Lab; D229 = Molec/cell Lab

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Journal Presentations: Schedule of topics

Date:


Topic:


3/23; 3/25

ssRNA viruses

3/30; 4/1

dsRNA viruses; retroviruses; hepadnaviruses

4/13; 4/15

DNA viruses

4/27; 4/29

Viroids; prions

5/4; 5/6

Infection control; vaccine development

5/11; 5/13

New & emerging viruses

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 Updated 1/24/04 by thatcher@sonoma.edu